使用聚苯乙烯功能化金纳米棒进行痕量癌症生物标志物定量分析。
Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods.
作者信息
Wu Jian, Li Wei, Hajisalem Ghazal, Lukach Ariella, Kumacheva Eugenia, Hof Fraser, Gordon Reuven
机构信息
Department of Electrical Engineering, University of Victoria, Victoria, British Columbia V8W 2Y2, Canada.
Department of Chemistry, University of Victoria, Victoria, British Columbia V8W 3V6, Canada.
出版信息
Biomed Opt Express. 2014 Nov 3;5(12):4101-7. doi: 10.1364/BOE.5.004101. eCollection 2014 Dec 1.
We demonstrate the application of polystyrene-functionalized gold nanorods (AuNRs) as a platform for surface enhanced Raman scattering (SERS) quantification of the exogenous cancer biomarker Acetyl Amantadine (AcAm). We utilize the hydrophobicity of the polystyrene attached to the AuNR surface to capture the hydrophobic AcAm from solution, followed by drying and detection using SERS. We achieve a detection limit of 16 ng/mL using this platform. This result shows clinical potential for low-cost early cancer detection.
我们展示了聚苯乙烯功能化金纳米棒（AuNRs）作为一种平台，用于对外源性癌症生物标志物乙酰金刚烷胺（AcAm）进行表面增强拉曼散射（SERS）定量分析。我们利用附着在AuNR表面的聚苯乙烯的疏水性从溶液中捕获疏水性的AcAm，然后进行干燥并使用SERS进行检测。使用该平台，我们实现了16 ng/mL的检测限。这一结果显示了其在低成本早期癌症检测方面的临床潜力。
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