Andersen Vibeke, Kopp Tine Iskov, Tjønneland Anne, Vogel Ulla
Organ Center, Hospital of Southern Jutland, 6200 Aabenraa, Denmark.
National Food Institute, 2860 Soborg, Denmark.
Int J Mol Sci. 2015 Jan 7;16(1):1375-84. doi: 10.3390/ijms16011375.
Red meat is a risk factor for colorectal cancer (CRC). We wanted to evaluate whether a functional polymorphism in the HMOX1 gene encoding heme oxygenase modifies risk of CRC or interacts with diet or lifestyle factors because this would identify heme or heme iron as a risk factor of CRC. The HMOX1 A-413T (rs2071746) was assessed in relation to risk of colorectal cancer (CRC) and interactions with diet (red meat, fish, fiber, cereals, fruit and vegetables) and lifestyle (use of non-steroidal anti-inflammatory drug and smoking status) were assessed in a case-cohort study of 928 CRC cases and a comparison group of 1726 randomly selected participants from a prospective study of 57,053 persons. No association between HMOX1 A-413T and CRC risk was found (TT vs. AA + TA; IRR = 1.15, 95% CI: 0.98-1.36, p = 0.10 for the adjusted estimate). No interactions were found between diet or lifestyle and HMOX1 A-413T. HMOX1 A-413T was not associated with CRC risk and no interactions with diet or lifestyle were identified in this large, prospective cohort with high meat intake. The results reproduced the previous findings from the same cohort and did not support a link between heme or heme iron and colorectal cancer. These results should be sought and replicated in other well-characterized cohorts with high meat intake.
红肉是结直肠癌（CRC）的一个风险因素。我们想要评估编码血红素加氧酶的HMOX1基因中的功能性多态性是否会改变CRC风险，或者是否与饮食或生活方式因素相互作用，因为这将确定血红素或血红素铁是CRC的一个风险因素。在一项对928例CRC病例以及从一项针对57,053人的前瞻性研究中随机选取的1726名参与者组成的对照组进行的病例队列研究中，评估了HMOX1 A-413T（rs2071746）与结直肠癌（CRC）风险的关系，并评估了其与饮食（红肉、鱼类、纤维、谷物、水果和蔬菜）及生活方式（使用非甾体抗炎药和吸烟状况）的相互作用。未发现HMOX1 A-413T与CRC风险之间存在关联（TT与AA + TA相比；调整后的估计值的IRR = 1.15，95% CI：0.98 - 1.36，p = 0.10）。未发现饮食或生活方式与HMOX1 A-413T之间存在相互作用。在这个肉类摄入量高的大型前瞻性队列中，HMOX1 A-413T与CRC风险无关，且未发现其与饮食或生活方式存在相互作用。这些结果重现了同一队列先前的研究结果，并不支持血红素或血红素铁与结直肠癌之间存在联系。这些结果应在其他肉类摄入量高且特征明确的队列中进行探索和验证。
