人类免疫缺陷病毒感染母亲母乳中的结核菌素γ干扰素反应
Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers.
作者信息
Cranmer L M, Kanyugo M, Lohman-Payne B, Tapia K, John-Stewart G C
机构信息
Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA; Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
出版信息
Int J Tuberc Lung Dis. 2015 Feb;19(2):141-3. doi: 10.5588/ijtld.14.0384.
Tuberculosis (TB) cellular immune responses were examined in the breast milk of human immunodeficiency virus infected mothers using the T-SPOT. TB interferon-gamma release assay (IGRA). Positive TB interferon-gamma (IFN-γ) responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breast milk and blood assays, TB IFN-γ responses were higher in breast milk than in blood (P = 0.02). The magnitude of TB IFN-γ responses in maternal breast milk and blood were correlated. Elucidating the influence of TB immune responses in breast milk on infant TB susceptibility and immunity may inform future maternal TB vaccine strategies.
利用T-SPOT.TB干扰素-γ释放试验（IGRA）检测了感染人类免疫缺陷病毒的母亲母乳中的结核（TB）细胞免疫反应。在8份有效的母乳检测中，有6份（75%）检测到结核干扰素-γ（IFN-γ）阳性反应。在7位同时进行母乳和血液检测的母亲中，母乳中的结核IFN-γ反应高于血液中的反应（P = 0.02）。母亲母乳和血液中结核IFN-γ反应的强度具有相关性。阐明母乳中结核免疫反应对婴儿结核易感性和免疫力的影响，可能为未来的母亲结核疫苗策略提供依据。
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