与胆红素诱导的神经损伤相关的听力障碍。
Audiologic impairment associated with bilirubin-induced neurologic damage.
作者信息
Olds Cristen, Oghalai John S
机构信息
Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA.
Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA.
出版信息
Semin Fetal Neonatal Med. 2015 Feb;20(1):42-46. doi: 10.1016/j.siny.2014.12.006. Epub 2015 Jan 7.
Abstract
Hyperbilirubinemia occurs commonly in neonates and is usually mild and transient, with no long-lasting sequelae. However, bilirubin-induced neurologic damage may occur in some infants. The auditory pathway is the most sensitive part of the central nervous system to bilirubin-induced toxicity, and permanent sequelae may result from only moderately elevated total serum/plasma bilirubin levels. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder.
摘要
高胆红素血症在新生儿中很常见，通常症状轻微且为一过性，不会留下长期后遗症。然而，一些婴儿可能会发生胆红素诱导的神经损伤。听觉通路是中枢神经系统中对胆红素诱导的毒性最敏感的部分，仅血清/血浆总胆红素水平适度升高就可能导致永久性后遗症。听觉系统的损伤主要发生在脑干和第八对脑神经，临床上表现为听觉神经病谱系障碍。
相似文献
1
Audiologic impairment associated with bilirubin-induced neurologic damage.与胆红素诱导的神经损伤相关的听力障碍。
Semin Fetal Neonatal Med. 2015 Feb;20(1):42-46. doi: 10.1016/j.siny.2014.12.006. Epub 2015 Jan 7.
2
Bilirubin-Induced Audiologic Injury in Preterm Infants.早产儿胆红素诱导的听力损伤
Clin Perinatol. 2016 Jun;43(2):313-23. doi: 10.1016/j.clp.2016.01.006. Epub 2016 Feb 15.
3
Auditory impairment in infants at risk for bilirubin-induced neurologic dysfunction.胆红素引起的神经功能障碍高危婴儿的听力损伤。
Semin Perinatol. 2011 Jun;35(3):162-70. doi: 10.1053/j.semperi.2011.02.011.
4
Short- and long-term outcome of severe neonatal nonhemolytic hyperbilirubinemia.重度新生儿非溶血性高胆红素血症的短期和长期预后
J Child Neurol. 2006 Apr;21(4):309-15. doi: 10.1177/08830738060210040301.
5
Bilirubin toxicity in the developing nervous system.发育中神经系统的胆红素毒性。
Pediatr Neurol. 2003 Nov;29(5):410-21. doi: 10.1016/j.pediatrneurol.2003.09.011.
6
Movement disorders due to bilirubin toxicity.胆红素毒性所致运动障碍。
Semin Fetal Neonatal Med. 2015 Feb;20(1):20-25. doi: 10.1016/j.siny.2014.11.002. Epub 2014 Dec 16.
7
Brainstem evoked response audiometry (BAER) in neonates with hyperbilirubinemia.高胆红素血症新生儿的脑干听觉诱发电位测定（BAER）
Indian J Pediatr. 2006 May;73(5):413-6. doi: 10.1007/BF02758564.
8
Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns.迈向理解核黄疸：改善黄疸新生儿管理的一项挑战。
Pediatrics. 2006 Feb;117(2):474-85. doi: 10.1542/peds.2005-0395.
9
Bilirubin-induced neurologic dysfunction (BIND).胆红素诱导的神经功能障碍（BIND）。
Semin Fetal Neonatal Med. 2015 Feb;20(1):1. doi: 10.1016/j.siny.2014.12.010. Epub 2015 Jan 7.
10
Hyperbilirubinemia and kernicterus.高胆红素血症和核黄疸。
Clin Perinatol. 2006 Jun;33(2):387-410. doi: 10.1016/j.clp.2006.03.010.
引用本文的文献
1
Late-Onset Auditory Neuropathy Spectrum Disorder in a 13-Year-Old: A Possible Association with Neonatal Jaundice.一名13岁儿童的迟发性听觉神经病谱系障碍：与新生儿黄疸的可能关联。
Indian J Otolaryngol Head Neck Surg. 2025 Mar;77(3):1678-1683. doi: 10.1007/s12070-025-05388-6. Epub 2025 Feb 13.
2
Bilirubin Triggers Calcium Elevations and Dysregulates Giant Depolarizing Potentials During Rat Hippocampus Maturation.胆红素在大鼠海马成熟过程中引发钙升高并使巨大去极化电位失调。
Cells. 2025 Jan 23;14(3):172. doi: 10.3390/cells14030172.
3
Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model.使用化学交换饱和转移磁共振成像的新方法在大鼠模型中对体内未结合胆红素进行可视化研究。
ACS Chem Neurosci. 2024 Dec 18;15(24):4533-4543. doi: 10.1021/acschemneuro.4c00604. Epub 2024 Nov 30.
4
Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.胆红素对新生脑内 GABA 能抑制性中间神经元的选择性神经毒性作用。
J Neurosci. 2024 Nov 6;44(45):e0442242024. doi: 10.1523/JNEUROSCI.0442-24.2024.
5
Developmental outcome of neonates underwent exchange transfusion due to hyperbilirubinemia: A single-center experience.因高胆红素血症接受换血治疗的新生儿的发育结局：单中心经验
J Educ Health Promot. 2024 Jul 11;13:209. doi: 10.4103/jehp.jehp_895_23. eCollection 2024.
6
Magnetic resonance spectroscopy and auditory brain-stem response audiometry as predictors of bilirubin-induced neurologic dysfunction in full-term jaundiced neonates.磁共振波谱和听觉脑干反应测听法作为足月黄疸新生儿胆红素诱导神经功能障碍的预测指标
Eur J Pediatr. 2024 Feb;183(2):727-738. doi: 10.1007/s00431-023-05246-z. Epub 2023 Nov 18.
7
Globus pallidus/putamen TWI signal intensity ratio in grading and predicting prognosis of neonatal acute bilirubin encephalopathy.苍白球/壳核TWI信号强度比值在新生儿急性胆红素脑病分级及预后预测中的应用
Front Pediatr. 2023 Sep 29;11:1192126. doi: 10.3389/fped.2023.1192126. eCollection 2023.
8
Hyperbilirobinemia and Its Effect on Auditory Perception and Speech Intelligibility in Cochlear Implanted Children (Cochlear Implantation Outcomes in Children Who Have Experienced Hyperbilirobinemia).高胆红素血症及其对人工耳蜗植入儿童听觉感知和言语清晰度的影响（经历过高胆红素血症儿童的人工耳蜗植入效果）
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):4144-4149. doi: 10.1007/s12070-021-02877-2. Epub 2021 Sep 21.
9
Bilirubin Encephalopathy.胆红素脑病。
Curr Neurol Neurosci Rep. 2022 Jul;22(7):343-353. doi: 10.1007/s11910-022-01204-8. Epub 2022 May 19.
10
Clinical Assessment of Neuroinflammatory Markers and Antioxidants in Neonates with Hyperbilirubinemia and Their Association with Acute Bilirubin Encephalopathy.高胆红素血症新生儿神经炎症标志物和抗氧化剂的临床评估及其与急性胆红素脑病的关联
Children (Basel). 2022 Apr 14;9(4):559. doi: 10.3390/children9040559.
本文引用的文献
1
Hearing and neurological impairment in children with history of exchange transfusion for neonatal hyperbilirubinemia.有新生儿高胆红素血症换血史儿童的听力和神经功能损害
Int J Pediatr. 2014;2014:605828. doi: 10.1155/2014/605828. Epub 2014 Feb 9.
2
Prestin regulation and function in residual outer hair cells after noise-induced hearing loss.噪声性听力损失后残余外毛细胞中 Prestin 的调控与功能
PLoS One. 2013 Dec 20;8(12):e82602. doi: 10.1371/journal.pone.0082602. eCollection 2013.
3
Brainstem auditory electrophysiology is supressed in term neonates with hyperbilirubinemia.脑桥听觉电生理学在高胆红素血症的足月新生儿中受到抑制。
Eur J Paediatr Neurol. 2014 Mar;18(2):193-200. doi: 10.1016/j.ejpn.2013.11.004. Epub 2013 Nov 18.
4
Reversibility of brainstem evoked response audiometry abnormalities at 3 months in term newborns with hyperbilirubinemia.足月新生儿高胆红素血症3个月时脑干听觉诱发电位异常的可逆性
Indian Pediatr. 2014 Feb;51(2):134-5. doi: 10.1007/s13312-014-0346-7. Epub 2013 Sep 5.
5
Auditory critical periods: a review from system's perspective.听觉关键期：系统视角的综述。
Neuroscience. 2013 Sep 5;247:117-33. doi: 10.1016/j.neuroscience.2013.05.021. Epub 2013 May 21.
6
Evaluation of treatment thresholds for unconjugated hyperbilirubinemia in preterm infants: effects on serum bilirubin and on hearing loss?评估早产儿未结合高胆红素血症的治疗阈值：对血清胆红素和听力损失的影响？
PLoS One. 2013 May 7;8(5):e62858. doi: 10.1371/journal.pone.0062858. Print 2013.
7
Auditory risk of hyperbilirubinemia in term newborns: a systematic review.足月儿高胆红素血症的听觉风险：一项系统综述
Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):898-905. doi: 10.1016/j.ijporl.2013.03.029. Epub 2013 Apr 30.
8
Impaired function of the auditory brainstem in term neonates with hyperbilirubinemia.足月新生儿高胆红素血症时听觉脑干功能受损。
Brain Dev. 2014 Mar;36(3):212-8. doi: 10.1016/j.braindev.2013.03.003. Epub 2013 Apr 12.
9
Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy.出院前筛查严重新生儿高胆红素血症可识别出需要光疗的婴儿。
J Pediatr. 2013 Mar;162(3):477-482.e1. doi: 10.1016/j.jpeds.2012.08.022. Epub 2012 Oct 5.
10
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation.未结合胆红素所致神经毒性的演变态势：神经胶质细胞与炎症的作用
Front Pharmacol. 2012 May 29;3:88. doi: 10.3389/fphar.2012.00088. eCollection 2012.
Zotero 插件