Zhang Shang-Hong
Key Laboratory of Gene Engineering of Ministry of Education, and Biotechnology Research Center, Sun Yat-sen University, Guangzhou 510275, China.
J Theor Biol. 2015 Apr 7;370:202-4. doi: 10.1016/j.jtbi.2014.12.014. Epub 2015 Jan 6.
Afreixo, V., Bastos, C.A.C., Garcia, S.P., Rodrigues, J.M.O.S., Pinho, A.J., Ferreira, P.J.S.G., 2013. The breakdown of the word symmetry in the human genome. J. Theor. Biol. 335, 153-159 analyzed the word symmetry (strand symmetry or the second parity rule) in the human genome. They concluded that strand symmetry holds for oligonucleotides up to 6 nt and is no longer statistically significant for oligonucleotides of higher orders. However, although they provided some new results for the issue, their interpretation would not be fully justified. Also, their conclusion needs to be further evaluated. Further analysis of their results, especially those of equivalence tests and word symmetry distance, shows that strand symmetry would persist for higher-order oligonucleotides up to 9 nt in the human genome, at least for its overall frequency framework (oligonucleotide frequency pattern).
阿弗雷ixo，V.，巴斯托斯，C.A.C.，加西亚，S.P.，罗德里格斯，J.M.O.S.，皮尼奥，A.J.，费雷拉，P.J.S.G.，2013年。人类基因组中词对称性的分解。《理论生物学杂志》335卷，第153 - 159页分析了人类基因组中的词对称性（链对称性或第二奇偶性规则）。他们得出结论，对于长度达6个核苷酸的寡核苷酸，链对称性成立，而对于更高阶的寡核苷酸，在统计学上不再显著。然而，尽管他们为该问题提供了一些新结果，但其解释并不完全合理。此外，他们的结论需要进一步评估。对他们结果的进一步分析，特别是等价性测试和词对称性距离的结果表明，在人类基因组中，链对称性对于长度达9个核苷酸的高阶寡核苷酸至少在其总体频率框架（寡核苷酸频率模式）下会持续存在。
