[Effect of the microencapsulation process parameters piroxicam by complex coacervation].
作者信息
Lamoudi L, Chaumeil J-C, Daoud K
机构信息
Laboratoire des phénomènes de transfert, faculté de génie mécanique et de génie des procédés, université des sciences et de la technologie Houari Boumediene, BP 32 El Alia, Bab Ezzouar, Alger, Algérie.
Labratoire de pharmacie galénique, faculté des sciences pharmaceutiques et biologiques, université Paris Descartes, 95270 Paris cedex 06, France.
出版信息
Ann Pharm Fr. 2015 Jan;73(1):37-42. doi: 10.1016/j.pharma.2014.05.006. Epub 2014 Jun 26.
INTRODUCTION
The gelatin-acacia system is used for the microencapsulation of piroxicam by complex coacervation.
MATERIALS AND METHODS
The effect of some formulation parameters and process, namely the ratio of gelatin/gum acacia, core/wall ratio, concentration of crosslinking agent and crosslinking time are studied. The microcapsules properties are evaluated.
RESULTS
The results showed that the microcapsules have a spherical shape, a coacervation efficiency greater than 70%, an average diameter less than 250 microns, a good stability and finally, the better values are obtained for gelatin/acacia ratio (5/3), ratio core/wall (1/4), an amount of 2 mL of crosslinking agent and a crosslinking time of 60 minutes.
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