通过巧妙的化学方法发现两类新型强效单胺氧化酶-B抑制剂。
Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry.
作者信息
Cagide F, Silva T, Reis J, Gaspar A, Borges F, Gomes L R, Low J N
机构信息
CIQUP/Departamento de Química e Bioquímica Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.
出版信息
Chem Commun (Camb). 2015 Feb 18;51(14):2832-5. doi: 10.1039/c4cc08798d.
PMID:25579652
Abstract
The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.
摘要
发现强效且具有选择性的单胺氧化酶 -B抑制剂用于治疗诸如阿尔茨海默病和帕金森病等神经退行性疾病仍是一项具有挑战性的工作。在此，我们报告基于苯并二氢吡喃 -2,4-二酮和色酮 -3-甲酰胺支架发现了两类新型强效且具有选择性的单胺氧化酶 -B抑制剂。
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