重度/极重度高甘油三酯血症与低密度脂蛋白分离治疗：文献综述及原始研究结果
Severe/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original Findings.
作者信息
Diakoumakou Olga, Hatzigeorgiou Georgios, Gontoras Nikos, Boutsikou Maria, Kolovou Vana, Mavrogeni Sophie, Giannakopoulou Vassiliki, Kolovou Genovefa D
机构信息
Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece ; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
出版信息
Cholesterol. 2014;2014:109263. doi: 10.1155/2014/109263. Epub 2014 Dec 16.
Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.
高甘油三酯血症（HTG）是包括血脂异常、代谢综合征和2型糖尿病在内的多种代谢紊乱的一个特征，并且会增加早发性冠状动脉疾病的风险。HTG也可能归因于遗传因素（称为原发性HTG），尤其是严重/极端HTG（SEHTG），这是一种通常较为罕见的遗传性疾病。由自身免疫性疾病引起的SEHTG继发性病例更为罕见。本综述探讨了SEHTG的病因及其管理，包括低密度脂蛋白单采治疗，并分析了原始研究结果。
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