劳拉西泮对人胎儿脑镁离子及（钠钾）三磷酸腺苷酶的体外作用
In vitro effect of lorazepam on Mg2+ and (Na+,K+) ATPases of human foetal brain.
作者信息
Saha U K, Sengupta T, Dutta C, Sirkar A, Sengupta D
出版信息
Indian J Exp Biol. 1989 Jan;27(1):44-6.
PMID:2558074
Abstract
Lorazepam (LZ), a benzodiazepine group of drug, inhibits Mg2+ and (Na+,K+) ATPases (EC 3.6.1.3) activity of human foetal and adult brain. The inhibitory effect neither varied with respect to the region (i.e. cerebrum and cerebellum) nor with the age of the foetus. The inhibition of ATPases activity indicates that the neuronal transmission processes, may be affected and raises the possibility of developmental disturbances.
摘要
劳拉西泮（LZ）是一种苯二氮䓬类药物，可抑制人胎儿和成人脑内的Mg2+和（Na+，K+）ATP酶（EC 3.6.1.3）活性。这种抑制作用在脑区（即大脑和小脑）方面以及胎儿年龄方面均无变化。ATP酶活性的抑制表明神经元传递过程可能受到影响，并增加了发育障碍的可能性。
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