Storz Corinna, Meindl Michael, Matuja William, Schmutzhard Erich, Winkler Andrea S
Department of Neurology, Technical University of Munich, Munich, Germany.
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Pediatr Res. 2015 Apr;77(4):591-6. doi: 10.1038/pr.2015.3. Epub 2015 Jan 12.
The prevalence of febrile seizures (FSs) and epilepsy are often reported to be higher in sub-Saharan Africa. Furthermore, several studies describe complex features of FSs as risk factors for the development of subsequent epilepsy.
During the period from 2002 to 2004 door-to-door studies with supplementary data collection were conducted in three different areas of Tanzania, examining the prevalence of FSs in 7,790 children between the age of 2 mo and 7 y at the time of the interview. The information on the presence of FSs of 14,583 children, who at the time of the interview were younger than 15 y, was collected in order to describe reported seizures, if any.
Overall, 160 children between 2 mo and 7 y with a prevalence rate of 20.5/1,000 (95% confidence interval: 17.5-23.9/1,000) met the criteria for FSs. The average age at onset was 2.2 (SD: 1.8) y and ~42% had complex FSs. Respiratory tract infections and malaria were the most frequent concomitant diseases.
Our findings do not confirm the assumption of an increased prevalence of FSs in sub-Saharan Africa. However, the elevated number of complex FSs emphasizes the necessity of more reliable studies about FSs and its consequences.
据报道，撒哈拉以南非洲地区热性惊厥（FSs）和癫痫的患病率较高。此外，多项研究将FSs的复杂特征描述为后续癫痫发生的危险因素。
在2002年至2004年期间，在坦桑尼亚的三个不同地区进行了挨家挨户的研究，并收集补充数据，调查了访谈时年龄在2个月至7岁之间的7790名儿童中FSs的患病率。收集了14583名访谈时年龄小于15岁儿童的FSs存在情况信息，以描述所报告的癫痫发作（如有）。
总体而言，160名年龄在2个月至7岁之间的儿童符合FSs标准，患病率为20.5/1000（95%置信区间：17.5 - 23.9/1000）。发病的平均年龄为2.2（标准差：1.8）岁，约42%的儿童患有复杂性FSs。呼吸道感染和疟疾是最常见的伴随疾病。
我们的数据并未证实撒哈拉以南非洲地区FSs患病率增加的假设。然而，复杂性FSs数量的增加强调了对FSs及其后果进行更可靠研究的必要性。
