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在一家退伍军人医院实施CIWA-Ar酒精戒断方案。

Implementation of a CIWA-Ar alcohol withdrawal protocol in a veterans hospital.

作者信息

Waye Courtney, Wong Mark, Lee Shuko

机构信息

From the Pharmacy Service, South Texas Veterans Health Care System, San Antonio, the Pharmacotherapy Education & Research Center, University of Texas Health Science Center at San Antonio, the Pharmacotherapy Division, University of Texas at Austin College of Pharmacy, Austin, and Research & Development, South Texas Veterans Health Care System, San Antonio.

出版信息

South Med J. 2015 Jan;108(1):23-8. doi: 10.14423/SMJ.0000000000000216.

Abstract

OBJECTIVES

The South Texas Veterans Health Care System (STVHCS) implemented a Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised (CIWA-Ar)-based alcohol-withdrawal protocol in June 2013. The aim of this study was to determine the efficacy and safety of the new protocol. The primary objective was the evaluation of whether implementation of the CIWA-Ar alcohol-withdrawal protocol decreased the average length of hospital stay for patients admitted with alcohol withdrawal syndrome (AWS) as compared with treatment before the introduction of the protocol. Secondary endpoints evaluated benzodiazepine (BZD)-prescribing practices, use of adjunctive medications for AWS, and safety outcomes.

METHODS

We reviewed 748 admissions with documented AWS or alcohol-related diagnoses during the study periods of July 2012 to December 2012 (preprotocol) and July 2013 to December 2013 (postprotocol). Patients in the preprotocol group needed to have a scheduled dose of a BZD in the electronic medical record, and those assigned to the postprotocol group needed to have at least one documented CIWA-Ar note in their electronic medical record. Exclusion criteria included prior conditions that interfered with accurate treatment of alcohol withdrawal.

RESULTS

There were no statistical differences in baseline characteristics between groups. No difference was found in the primary endpoint of length of stay when comparing hospitalizations pre- and postprotocol implementation (3.84 ± 2.31 days vs 3.82 ± 2.7 days; P = 0.667). There was no statistical significance in total cumulative dose of BZD, daily dose of BZD, or duration of BZD use when compared pre- and postprotocol. No safety events requiring further intervention occurred.

CONCLUSIONS

Implementation of a CIWA-Ar protocol at our institution did not result in a decreased duration of hospital stay; however, a decline in prescribing fixed-schedule BZDs was documented.

摘要

目的

南德克萨斯退伍军人医疗保健系统(STVHCS)于2013年6月实施了基于修订版酒精戒断临床研究所评估量表(CIWA-Ar)的酒精戒断方案。本研究的目的是确定新方案的疗效和安全性。主要目标是评估与该方案引入前的治疗相比,CIWA-Ar酒精戒断方案的实施是否缩短了因酒精戒断综合征(AWS)入院患者的平均住院时间。次要终点评估苯二氮䓬(BZD)的处方习惯、AWS辅助药物的使用以及安全结局。

方法

我们回顾了2012年7月至2012年12月(方案实施前)和2013年7月至2013年12月(方案实施后)期间748例有记录的AWS或酒精相关诊断的入院病例。方案实施前组的患者在电子病历中需要有预定剂量的BZD,而分配到方案实施后组的患者在电子病历中需要至少有一份记录的CIWA-Ar记录。排除标准包括先前干扰酒精戒断准确治疗的情况。

结果

两组间基线特征无统计学差异。比较方案实施前后的住院时间,主要终点无差异(3.84±2.31天对3.82±2.7天;P = 0.667)。比较方案实施前后,BZD的总累积剂量、每日剂量或使用持续时间均无统计学意义。未发生需要进一步干预的安全事件。

结论

在我们机构实施CIWA-Ar方案并未缩短住院时间;然而,记录显示固定时间表BZD的处方量有所下降。

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