Pleşa Alina, Sarca Emanuela, Maxim Roxana
University of Medicine and Pharmacy Grigore T. Popa - Iaşi, Department of Medical Specialties (I).
Rev Med Chir Soc Med Nat Iasi. 2014 Oct-Dec;118(4):1018-23.
Carcinoid tumor is a slow-growing type of neuroendocrine tumor, originating in the enterochromaffin cells and secreting mainly serotonin. Neuroendocrine tumors (NETs) are found throughout the intestinal tract, the appendix and terminal ileum being the most common locations, and are classified by site of origin and by degree of differentiation, with well-differentiated lesions representing those tumors formerly referred to as carcinoid tumors. The clinical symptoms are characterized by flushing, diarrhea, abdominal pain, and/or bronchial constriction and occur almost exclusively in patients with liver metastases due to the release of bioactive peptides and amines directly into the systemic circulation. We report the clinical, serological and histological diagnosis of a 67-years-old male patient with congestive heart failure secondary to carcinoid heart disease in the context of liver metastases of an ileum carcinoid tumor.
类癌肿瘤是一种生长缓慢的神经内分泌肿瘤，起源于肠嗜铬细胞，主要分泌5-羟色胺。神经内分泌肿瘤（NETs）可在整个肠道中发现，阑尾和回肠末端是最常见的部位，根据起源部位和分化程度进行分类，高分化病变即以前称为类癌肿瘤的那些肿瘤。临床症状的特征为潮红、腹泻、腹痛和/或支气管收缩，几乎仅发生于因生物活性肽和胺直接释放到体循环而出现肝转移的患者。我们报告了一名67岁男性患者的临床、血清学和组织学诊断，该患者在回肠类癌肿瘤肝转移的情况下继发类癌心脏病并伴有充血性心力衰竭。
