Orlando Nicoletta, Putzulu Rossana, Massini Giuseppina, Scavone Fernando, Piccirillo Nicola, Maresca Maddalena, Zini Gina, Teofili Luciana
Transfusion Medicine Department, Università Cattolica Sacro Cuore, L.go A.Gemelli, Rome 8- 00168, Italy.
Transfusion Medicine Department, Università Cattolica Sacro Cuore, L.go A.Gemelli, Rome 8- 00168, Italy.
Transfus Apher Sci. 2015 Apr;52(2):217-9. doi: 10.1016/j.transci.2014.12.020. Epub 2014 Dec 19.
The weak D phenotype is represented by a group of RHD genotypes that code for alterated RhD proteins associated with a reduced RhD expression on red blood cell. By routine serology, some partial D variants are likely to be missed. In this report we describe the case of a three-year-old Black African child with a "unclear" reaction with monoclonal anti-D. We analyzed the blood sample of the child with different methods to conclude that it is a case of DAR 1.2 (weak D 4.2.2) and that it must be transfused with D negative erithrocytes.
弱 D 表型由一组 RHD 基因型表示，这些基因型编码与红细胞上 RhD 表达减少相关的改变的 RhD 蛋白。通过常规血清学检测，一些部分 D 变异型可能会被漏检。在本报告中，我们描述了一名三岁的非洲黑人儿童，其与单克隆抗 -D 出现“不明确”反应的病例。我们用不同方法分析了该儿童的血样，得出这是一例 DAR 1.2（弱 D 4.2.2）的病例，且必须输注 D 阴性红细胞。
