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[肝癌粟粒性脑转移所致痴呆]

[Dementia caused by miliary cerebral metastasis of a hepatocarcinoma].

作者信息

Fontán A, Zarranz J J, Camarero C, Forcadas I

出版信息

Med Clin (Barc). 1989 Oct 14;93(11):421-3.

PMID:2558263
Abstract

Different types of tumors account for the etiology of 8.6% of all cases of dementia. Cerebral computed tomography (CT) permits the detection of most of them. The miliary metastasis variety commonly presents as dementia, and CT may then be normal. A patient with late epilepsy after cerebral infarction developed subacute dementia and he subsequently died. Post mortem study disclosed miliary cerebral metastases of a clinically unsuspected hepatocarcinoma. Cerebral CT did not detect the metastases. Although the incidence of hepatocarcinoma is increasing, we are unaware of any similar reported case, as cerebral involvement is exceptional in this condition. Despite its rarity, this case highlights the need to perform thorough neuropathological investigations in dementia.

摘要

不同类型的肿瘤占所有痴呆病例病因的8.6%。脑部计算机断层扫描(CT)能够检测出其中的大多数。粟粒性转移瘤通常表现为痴呆,而此时CT可能显示正常。一名脑梗死后出现晚期癫痫的患者发展为亚急性痴呆,随后死亡。尸检研究发现了临床上未被怀疑的肝癌的粟粒性脑转移瘤。脑部CT未检测到这些转移瘤。尽管肝癌的发病率在上升,但我们尚未知晓有任何类似的报道病例,因为在这种情况下脑部受累情况较为罕见。尽管该病例罕见,但它凸显了对痴呆患者进行全面神经病理学检查的必要性。

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