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[肝癌粟粒性脑转移所致痴呆]

[Dementia caused by miliary cerebral metastasis of a hepatocarcinoma].

作者信息

Fontán A, Zarranz J J, Camarero C, Forcadas I

出版信息

Med Clin (Barc). 1989 Oct 14;93(11):421-3.

PMID:2558263
Abstract

Different types of tumors account for the etiology of 8.6% of all cases of dementia. Cerebral computed tomography (CT) permits the detection of most of them. The miliary metastasis variety commonly presents as dementia, and CT may then be normal. A patient with late epilepsy after cerebral infarction developed subacute dementia and he subsequently died. Post mortem study disclosed miliary cerebral metastases of a clinically unsuspected hepatocarcinoma. Cerebral CT did not detect the metastases. Although the incidence of hepatocarcinoma is increasing, we are unaware of any similar reported case, as cerebral involvement is exceptional in this condition. Despite its rarity, this case highlights the need to perform thorough neuropathological investigations in dementia.

摘要

不同类型的肿瘤占所有痴呆病例病因的8.6%。脑部计算机断层扫描(CT)能够检测出其中的大多数。粟粒性转移瘤通常表现为痴呆,而此时CT可能显示正常。一名脑梗死后出现晚期癫痫的患者发展为亚急性痴呆,随后死亡。尸检研究发现了临床上未被怀疑的肝癌的粟粒性脑转移瘤。脑部CT未检测到这些转移瘤。尽管肝癌的发病率在上升,但我们尚未知晓有任何类似的报道病例,因为在这种情况下脑部受累情况较为罕见。尽管该病例罕见,但它凸显了对痴呆患者进行全面神经病理学检查的必要性。

相似文献

1
[Dementia caused by miliary cerebral metastasis of a hepatocarcinoma].[肝癌粟粒性脑转移所致痴呆]
Med Clin (Barc). 1989 Oct 14;93(11):421-3.
2
Massive cerebral hemorrhage from metastatic hepatocellular carcinoma.转移性肝细胞癌导致的大量脑出血。
J Med Assoc Thai. 1991 Nov;74(11):531-8.
3
Intracranial hemorrage due to brain metastases in an Italian HCV patient with hepatocellular carcinoma.一名患有肝细胞癌的意大利丙型肝炎病毒患者因脑转移导致颅内出血。
J Exp Clin Cancer Res. 2003 Dec;22(4):641-4.
4
Recurrent metastatic hepatocellular carcinoma presenting as consecutive "mirror image" intracerebral haematomas.复发性转移性肝细胞癌表现为连续性“镜像”脑内血肿。
J Clin Neurosci. 2005 Aug;12(6):699-702. doi: 10.1016/j.jocn.2004.08.026.
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[Combined chronic subdural and acute epidural hematoma secondary to metastatic hepatocellular cancer: case report].[转移性肝细胞癌继发慢性硬膜下血肿合并急性硬膜外血肿:病例报告]
No Shinkei Geka. 1999 Apr;27(4):331-4.
6
[Metastatic hepatoma presenting as intracranial hemorrhage: report of two cases].
No To Shinkei. 1988 Oct;40(10):919-24.
7
[Case presentation at the Salpétrière hospital. January 1991. Late epilepsy and dementia syndrome with subacute development in a 56 year-old man].[1991年1月于萨尔佩特里埃医院的病例报告。一名56岁男性亚急性起病的迟发性癫痫和痴呆综合征]
Rev Neurol (Paris). 1993;149(1):65-70.
8
Intracranial metastasis of hepatocellular carcinoma: review of 45 cases.肝细胞癌颅内转移:45例病例回顾
Surg Neurol. 2004 Aug;62(2):172-7. doi: 10.1016/j.surneu.2003.10.002.
9
Brain metastases from hepatocellular carcinoma. A case report.肝细胞癌脑转移:一例报告
J Neurosurg Sci. 2002 Jun;46(2):77-80; discussion 80.
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[An autopsy case of miliary brain metastases].[一例粟粒性脑转移瘤尸检病例]
No To Shinkei. 2006 Feb;58(2):161-5.

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Miliary brain metastases from primary gastric small cell carcinoma: illustrating the seed and soil hypothesis.
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