Kaneko C, Matsumoto H, Hara S, Takeuchi T, Mori T, Ikeda K, Mizuno Y
Minophargen Research Laboratory, Kanagawa, Japan.
Nucleic Acids Symp Ser. 1989(21):129-30.
Several tri-O -acetyl-1-beta-D -ribofuranosyl- and 2-acetoxyethoxymethylimidazo[4,5-d][1,3]thiazine derivatives 5-10 were synthesized from imidazo[4,5-d][1,3]thiazine 4 and tetra-O -acetyl-beta-D -ribofuranose or 2-acetoxyethoxymethyl acetate by fusion method. In each case, depending on the substituent on position 5 of thiazine skeleton, only N3 isomer or both N1 and N3 isomers (in different ratios) were obtained.
