8-Methyladenosine-substituted analogs of 2-5A: synthesis and properties.
作者信息
Kitade Y, Nakata Y, Hirota K, Maki Y, Pabuccoglu A, Torrence P F
机构信息
Medicinal Chemistry, Gifu Pharmaceutical University, Japan.
出版信息
Nucleic Acids Symp Ser. 1989(21):93-4.
PMID:2558355
Abstract
Four 8-methyladenosine-substituted analogs of 2-5A were obtained by a synthesis which involved a modification of the lead ion-catalyzed ligation reaction. Substituent of an 8-methyladenosine residue at the third position (2'-terminal) of the oligonucleotides increased the stability to snake venom phosphodiesterase digestion.
摘要
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