Yang Hong, Shu Yan
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD 21201, USA.
Int J Mol Sci. 2015 Jan 9;16(1):1484-94. doi: 10.3390/ijms16011484.
Among the organs in which the environmental pollutant cadmium causes toxicity, the kidney has gained the most attention in recent years. Numerous studies have sought to unravel the exact pathways by which cadmium enters the renal epithelial cells and the mechanisms by which it causes toxicity in the kidney. The purpose of this review is to present the progress made on the mechanisms of cadmium transport in the kidney and the role of transporter proteins in cadmium-induced nephrotoxicity.
在环境污染物镉会产生毒性的器官中，肾脏近年来受到了最多关注。众多研究试图阐明镉进入肾上皮细胞的确切途径以及它在肾脏中产生毒性的机制。本综述的目的是介绍在肾脏中镉转运机制以及转运蛋白在镉诱导的肾毒性中的作用方面所取得的进展。
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