Randall W C, Talano J, Kaye M P, Euler D, Jones S, Brynjolfsson G
Am J Physiol. 1978 Apr;234(4):H465-70. doi: 10.1152/ajpheart.1978.234.4.H465.
Surgical excision of the sinoatrial node, verified histologically, is followed by a supraventricular (atrial) rhythm in both resting and exercising dog whether anesthetized or conscious. The ECG is characterized by a definitive P wave and associated atrial electrograms. Waxing and waning in heart rate, generally referred to as sinus arrhythmia continues in the awake animal after complete excision of the SA node. This arrhythmia is responsive to both adrenergic and cholinergic interventions, thus indicating the presence of both sympathetic and parasympathetic regulation of subsidiary atrial pacemaking tissues.
经组织学证实，对窦房结进行手术切除后，无论是麻醉还是清醒状态下的犬，在静息和运动时均会出现室上性（心房）节律。心电图的特征是有明确的P波及相关的心房电图。在窦房结完全切除后，清醒动物的心率仍会出现波动，通常称为窦性心律失常。这种心律失常对肾上腺素能和胆碱能干预均有反应，因此表明存在对辅助心房起搏组织的交感神经和副交感神经调节。
