Bogenschutz Michael P, Forcehimes Alyssa A, Pommy Jessica A, Wilcox Claire E, Barbosa P C R, Strassman Rick J
Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
J Psychopharmacol. 2015 Mar;29(3):289-99. doi: 10.1177/0269881114565144. Epub 2015 Jan 13.
Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically relevant effects in alcohol and drug addiction. Although recent studies have investigated the effects of psilocybin in various populations, there have been no studies on the efficacy of psilocybin for alcohol dependence. We conducted a single-group proof-of-concept study to quantify acute effects of psilocybin in alcohol-dependent participants and to provide preliminary outcome and safety data. Ten volunteers with DSM-IV alcohol dependence received orally administered psilocybin in one or two supervised sessions in addition to Motivational Enhancement Therapy and therapy sessions devoted to preparation for and debriefing from the psilocybin sessions. Participants' responses to psilocybin were qualitatively similar to those described in other populations. Abstinence did not increase significantly in the first 4 weeks of treatment (when participants had not yet received psilocybin), but increased significantly following psilocybin administration (p < 0.05). Gains were largely maintained at follow-up to 36 weeks. The intensity of effects in the first psilocybin session (at week 4) strongly predicted change in drinking during weeks 5-8 (r = 0.76 to r = 0.89) and also predicted decreases in craving and increases in abstinence self-efficacy during week 5. There were no significant treatment-related adverse events. These preliminary findings provide a strong rationale for controlled trials with larger samples to investigate efficacy and mechanisms.
NCT02061293.
有几条证据表明，经典（5HT2A 激动剂）致幻剂在酒精和药物成瘾方面具有临床相关作用。尽管最近的研究调查了裸盖菇素在不同人群中的作用，但尚未有关于裸盖菇素治疗酒精依赖疗效的研究。我们进行了一项单组概念验证研究，以量化裸盖菇素对酒精依赖参与者的急性影响，并提供初步的结果和安全性数据。十名符合《精神疾病诊断与统计手册》第四版酒精依赖标准的志愿者，除接受动机增强疗法以及专门针对裸盖菇素治疗环节的准备和汇报的治疗环节外，还在一到两个有监督的疗程中口服了裸盖菇素。参与者对裸盖菇素的反应在质量上与其他人群中描述的相似。在治疗的前 4 周（参与者尚未接受裸盖菇素时）戒酒率没有显著增加，但在服用裸盖菇素后显著增加（p < 0.05）。这些改善在随访至 36 周时基本得以维持。第一次裸盖菇素治疗环节（第 4 周）的效果强度强烈预测了第 5 - 8 周饮酒量的变化（r = 0.76 至 r = 0.89），并且还预测了第 5 周时渴望程度的降低和戒酒自我效能感的提高。没有与治疗相关的显著不良事件。这些初步发现为进行更大样本的对照试验以研究疗效和机制提供了有力的理论依据。
NCT02061293。
