Pratt Judith A, Morris Brian J
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING), University of Glasgow and University of Strathclyde, Glasgow, UK
Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING), University of Glasgow and University of Strathclyde, Glasgow, UK Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
J Psychopharmacol. 2015 Feb;29(2):127-37. doi: 10.1177/0269881114565805. Epub 2015 Jan 13.
The thalamus (comprising many distinct nuclei) plays a key role in facilitating sensory discrimination and cognitive processes through connections with the cortex. Impaired thalamocortical processing has long been considered to be involved in schizophrenia. In this review we focus on the thalamic reticular nucleus (TRN) providing evidence for it being an important communication hub between the thalamus and cortex and how it may play a key role in the pathophysiology of schizophrenia. We first highlight the functional neuroanatomy, neurotransmitter localisation and physiology of the TRN. We then present evidence of the physiological roles of the TRN in relation to oscillatory activity, cognition and behaviour. Next we discuss the role of the TRN in rodent models of risk factors for schizophrenia (genetic and pharmacological) and provide evidence for TRN deficits in schizophrenia. Finally we discuss new drug targets for schizophrenia in relation to restoring TRN circuitry dysfunction.
丘脑（由许多不同的核团组成）通过与皮层的连接，在促进感觉辨别和认知过程中发挥关键作用。长期以来，丘脑皮质处理功能受损一直被认为与精神分裂症有关。在本综述中，我们聚焦于丘脑网状核（TRN），为其作为丘脑与皮层之间重要的通信枢纽提供证据，并探讨它如何在精神分裂症的病理生理学中发挥关键作用。我们首先强调TRN的功能性神经解剖学、神经递质定位和生理学。然后我们展示TRN在振荡活动、认知和行为方面生理作用的证据。接下来，我们讨论TRN在精神分裂症风险因素（遗传和药理学）的啮齿动物模型中的作用，并提供精神分裂症中TRN缺陷的证据。最后，我们讨论与恢复TRN电路功能障碍相关的精神分裂症新药靶点。
