Valerio Serena, Bracale Umberto Marcello, Giribono Anna Maria, Viviani Emanuela, Caioni Federica, del Guercio Luca
Ann Ital Chir. 2014 Nov 3;85(ePub):S2239253X14023019.
Pemetrexed and Carboplatin are two well-known chemioterapic agents used for the treatment of many tumors, especially for lung cancer and mesothelioma. Peripheral ischemic events related to Pemetrexed and Carboplatin are rarely reported. We herein report a case of lower limb acute ischemia related to combined treatment of Pemetrexed and Carboplatin. A 68-year-old woman was given the chemiotherapic treatment with combination of Pemetrexed and Carboplatin after pleural resection for a malignant pleural mesothelioma. Immediately after the second cycle of treatment, the patient experienced sudden acute left lower limb ischemia. Symptoms resolved after an intra-operative thrombolytic and spasmolytic therapy.
培美曲塞和顺铂是两种用于治疗多种肿瘤，尤其是肺癌和间皮瘤的著名化疗药物。与培美曲塞和顺铂相关的外周缺血事件鲜有报道。我们在此报告一例与培美曲塞和顺铂联合治疗相关的下肢急性缺血病例。一名68岁女性在因恶性胸膜间皮瘤行胸膜切除术后接受了培美曲塞和顺铂联合化疗。在第二个疗程治疗后不久，患者突然出现急性左下肢缺血。经术中溶栓和解痉治疗后症状缓解。
