Ivancev K, Lunderquist A, Isaksson A, Hochbergs P, Wretlind A
Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Acta Radiol. 1989 Sep-Oct;30(5):449-57.
A new iodinated lipid emulsion, Intraiodol, for which animal studies have indicated better tolerance than for other iodinated lipid emulsions, was tested in 15 patients with malignant lesions, and in one patient with focal nodular hyperplasia. Repeated CT scans of the liver and spleen and blood tests were performed for 24 hours after intravenous injection of Intraiodol. The uptake of Intraiodol in the liver (peak mean 28.6 HU) was higher than in the spleen (peak mean 21.8 HU). The uptake of Intraiodol in malignant lesions was minimal (peak mean 2.8 HU). The detection rate of hepatic lesions was equal to or better than that achieved by US, CT, and/or CT angiography. However, liver uptake of Intraiodol was low in 2 patients with severe fatty infiltration. Intraiodol produced vascular enhancement up to one hour after injection since it was eliminated slowly from the circulation. The observed adverse reactions consisted of temporary metallic taste in 5 of the patients, fever and exacerbation of back pain in one patient, and transient thrombocytopenia in one patient. Alkaline phosphatase increased (17%, p less than 0.01) only at two hours, and erythrocyte count (6%, p less than 0.05) at 24 hours after injection. Our initial results indicate diagnostic advantages of Intraiodol without serious adverse reactions. Further clinical studies are required to confirm these findings.
一种新型碘化脂质乳剂——碘油醇，动物研究表明其耐受性优于其他碘化脂质乳剂。对15例恶性病变患者和1例局灶性结节性增生患者进行了测试。静脉注射碘油醇后24小时内，对肝脏和脾脏进行了多次CT扫描并进行了血液检测。碘油醇在肝脏中的摄取量（峰值平均为28.6HU）高于脾脏（峰值平均为21.8HU）。碘油醇在恶性病变中的摄取量极少（峰值平均为2.8HU）。肝脏病变的检测率等于或优于超声、CT和/或CT血管造影所达到的检测率。然而，2例严重脂肪浸润患者肝脏对碘油醇的摄取量较低。由于碘油醇从循环中清除缓慢，注射后1小时内会产生血管强化。观察到的不良反应包括5例患者出现短暂的金属味，1例患者出现发热和背痛加重，1例患者出现短暂性血小板减少。注射后仅在两小时时碱性磷酸酶升高（17%，p<0.01），24小时时红细胞计数升高（6%，p<0.05）。我们的初步结果表明碘油醇具有诊断优势且无严重不良反应。需要进一步的临床研究来证实这些发现。
