Gasparík J
Institute of Health, Bratislava, Czechoslovakia.
Eur J Pharmacol. 1989 Dec 5;172(6):417-23. doi: 10.1016/0922-4106(89)90024-2.
Investigations of the conformation of endogenous enkephalins are generally based on structural comparisons of enkephalins with other opiates and on experimental pharmacological studies. Based on such investigations, we now propose a novel model of the biologically active (receptor-bound) conformation of [Met5]- and [Leu5]enkephalin on the delta opioid receptor. The model helps with the design of new opioid analgesics.
