Lopes Fernanda Cristina Rueda, Alves-Leon Soniza Vieira, Godoy Jose Mauricio, de Souza Batista Scherpenhuijzen Simone, Fezer Leticia, Gasparetto Emerson Leandro
Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, Niterói, Rio de Janeiro, Brazil.
Federal University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil.
J Neuroimaging. 2015 Sep-Oct;25(5):807-12. doi: 10.1111/jon.12191. Epub 2015 Jan 15.
Optic neuritis (ON) is an acute episode of inflammation in the visual pathway (VP). It may occur as part of a demyelinating disease, which can affect white matter (WM) throughout the VP. Compensatory cortical adaptations may occur following WM damage to maintain visual integrity. Our aim was to investigate whether resting-state functional MRI (rsfMRI) can detect cortical adaptations following ON attacks and to correlate rsfMRI with diffusion tensor imaging (DTI) of WM within the VP.
Neuromyelitis optica spectrum patients were compared to healthy controls at least 6 months after ON onset. DTI and rsfMRI were performed and post-processed using FSL tools (TBSS for DTI and MELODIC for fMRI).
Ptients had higher synchronization values than controls in the visual network (3.48 vs. 2.12, P < .05). A weak trend of correlation was revealed between fMRI and structural analysis by DTI using fractional anisotropy (right side: R = -.36, P < .08; left side: R = .075, P < .73).
The rsfMRI detected cortical reorganization following ON attack, but WM was considerably preserved in the posterior VP.
视神经炎（ON）是视觉通路（VP）的急性炎症发作。它可能作为脱髓鞘疾病的一部分出现，这种疾病可影响整个VP的白质（WM）。WM损伤后可能会发生代偿性皮质适应，以维持视觉完整性。我们的目的是研究静息态功能磁共振成像（rsfMRI）是否能检测ON发作后的皮质适应情况，并将rsfMRI与VP内WM的扩散张量成像（DTI）相关联。
将视神经脊髓炎谱系疾病患者与ON发作至少6个月后的健康对照进行比较。进行DTI和rsfMRI检查，并使用FSL工具（DTI用TBSS，fMRI用MELODIC）进行后处理。
患者在视觉网络中的同步值高于对照组（3.48对2.12，P <.05）。使用分数各向异性的DTI进行的fMRI与结构分析之间显示出微弱的相关趋势（右侧：R = -.36，P <.08；左侧：R =.075，P <.73）。
rsfMRI检测到ON发作后的皮质重组，但VP后部的WM得到了相当程度的保留。
