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两例使用神经肌肉阻滞剂自杀事件中的药物鉴定问题。

Drug identification problems in two suicides with neuromuscular blocking agents.

作者信息

Somogyi G, Varga M, Prokai L, Dinya Z, Buris L

机构信息

Institute of Forensic Medicine, Medical University of Debrecen, Hungary.

出版信息

Forensic Sci Int. 1989 Dec;43(3):257-66. doi: 10.1016/0379-0738(89)90153-9.

Abstract

Cases of suicide committed with neuromuscular blocking agents have been investigated. Both cases involved anesthesiologists who took the muscle relaxants suxamethonium chloride (Sukolin) or pipecuronium bromide (Arduan) and a rapid-acting barbiturate, 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin). The examinations were performed by using gas chromatography and mass spectrometry. The quantitative data obtained showed that doses useful in general anesthesiological practice were applied. Metabolites were found despite their fast metabolizing character.

摘要

已对使用神经肌肉阻滞剂实施自杀的案例展开调查。两起案例均涉及麻醉师,他们服用了肌肉松弛剂氯化琥珀胆碱(司可林)或哌库溴铵(阿端)以及速效巴比妥酸盐5-仲丁基-5-乙基-2-硫代巴比妥酸(安泰酮)。检测采用气相色谱法和质谱分析法进行。所获定量数据表明,使用的剂量为一般麻醉实践中常用的剂量。尽管这些物质代谢迅速,但仍发现了代谢物。

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