Tanizaki Hideaki, Yamamoto Yosuke, Nakamizo Satoshi, Otsuka Atsushi, Miyachi Yoshiki, Kabashima Kenji
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Pharmacology. 2015;95(1-2):32-5. doi: 10.1159/000370312. Epub 2015 Jan 13.
Olopatadine is one of the second-generation H1 antihistamines that were used for treating allergic disorders initially in Asia, and now also in Western countries. Whereas several trials compared the efficacy on chronic urticaria among second-generation H1 antihistamines, no study has directly compared the clinical efficacy between olopatadine and other H1 antihistamines in patients with chronic idiopathic urticaria (CIU). In this study, we address this issue for the first time and conclude that olopatadine is a good candidate for the treatment of CIU.
奥洛他定是第二代H1抗组胺药之一，最初在亚洲用于治疗过敏性疾病，现在西方国家也在使用。虽然有几项试验比较了第二代H1抗组胺药对慢性荨麻疹的疗效，但尚无研究直接比较奥洛他定与其他H1抗组胺药在慢性特发性荨麻疹（CIU）患者中的临床疗效。在本研究中，我们首次解决了这个问题，并得出结论：奥洛他定是治疗CIU的良好选择。
