Shimada Akiko, Baad-Hansen Lene, Castrillon Eduardo, Ghafouri Bijar, Stensson Niclas, Gerdle Björn, Ernberg Malin, Cairns Brian, Svensson Peter
Section of Clinical Oral Physiology, Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON).
Section of Clinical Oral Physiology, Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON).
Nutrition. 2015 Feb;31(2):315-23. doi: 10.1016/j.nut.2014.07.011. Epub 2014 Aug 12.
The aim of this study was to determine the relationship of high daily monosodium glutamate (MSG) consumption with glutamate concentrations in jaw muscle, saliva, and serum, and muscle pain sensitivity in healthy participants.
A randomized, double-blinded, placebo-controlled study was conducted to investigate the effect of repetitive consumption of high-dose MSG on glutamate concentration in the masseter muscles measured by microdialysis and muscle pain sensitivity. In five contiguous experimental daily sessions, 32 healthy participants drank MSG (150 mg/kg) or NaCl (24 mg/kg) diluted with a 400 mL soda. The concentrations of glutamate before and after the ingestion were assessed in dialysate and plasma samples on the first and last days. Saliva glutamate concentration was assessed every day. Pressure pain threshold, pressure pain tolerance, autonomic parameters (heart rate, systolic and diastolic blood pressures) and reported side effects also were assessed.
No significant change was noted in the baseline concentration of glutamate in the masseter muscle, blood, or saliva, but the peak concentration in the masseter muscle increased significantly between day 1 and 5. A statistically significant increase in systolic and diastolic blood pressures after MSG administration was observed, as well as a significantly higher frequency of reports of nausea and headache in the MSG group. No robust effect of MSG on muscle sensitivity was found.
Interstitial glutamate concentration in the masseter muscle is not highly disturbed by excessive repetitive intake of MSG in healthy man.
本研究旨在确定健康参与者每日高剂量摄入味精（MSG）与颌肌、唾液和血清中谷氨酸浓度以及肌肉疼痛敏感性之间的关系。
进行了一项随机、双盲、安慰剂对照研究，以调查重复高剂量摄入味精对通过微透析测量的咬肌中谷氨酸浓度和肌肉疼痛敏感性的影响。在连续五个实验日的时间段内，32名健康参与者饮用用400毫升苏打水稀释的味精（150毫克/千克）或氯化钠（24毫克/千克）。在第一天和最后一天评估透析液和血浆样本中摄入前后的谷氨酸浓度。每天评估唾液谷氨酸浓度。还评估了压痛阈值、压痛耐受性、自主参数（心率、收缩压和舒张压）以及报告的副作用。
咬肌、血液或唾液中谷氨酸的基线浓度未观察到显著变化，但咬肌中的峰值浓度在第1天和第5天之间显著增加。观察到服用味精后收缩压和舒张压有统计学意义的升高，以及味精组中恶心和头痛报告的频率显著更高。未发现味精对肌肉敏感性有明显影响。
在健康男性中，过量重复摄入味精不会严重干扰咬肌中的间质谷氨酸浓度。
