Zhou Jian-Rong, Syono Ryo-ichi, Fukumi Syu-ichi, Kimoto Kenji, Shirasaki Tetsuya, Soeda Fumio, Takahama Kazuo
Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Pharmacology. 2015;95(1-2):36-41. doi: 10.1159/000369977. Epub 2015 Jan 13.
We studied the antitussive effects of suplatast, a Th2 cytokine inhibitor, and compared them with the effects of codeine using an experimental cough model in guinea pigs. Suplatast and codeine dose-dependently inhibited cough caused by mechanical stimulation of the larynx, but they did not inhibit cough caused by mechanical stimulation of the bifurcation of the trachea. In guinea pigs with bronchitis, suplatast had an antitussive effect on cough caused by stimulation of the larynx, whereas codeine did not inhibit such cough. In SO2-exposed guinea pigs, suplatast tended to inhibit cough caused by mechanical stimulation of the tracheal bifurcation. Further, suplatast inhibited citric acid-induced cough augmented by pretreatment with an angiotensin-converting enzyme inhibitor, whereas codeine did not inhibit such cough. Suplatast also inhibited bradykinin-induced discharges of airway vagal afferent nerves and significantly inhibited 4-aminopyridine-induced discharges of airway vagal afferent nerves. These findings indicate that the antitussive effects of suplatast are mediated by a novel mechanism involving the peripheral nervous system.
我们研究了Th2细胞因子抑制剂色甘酸的镇咳作用，并在豚鼠实验性咳嗽模型中与可待因的作用进行了比较。色甘酸和可待因均呈剂量依赖性抑制由喉部机械刺激引起的咳嗽，但它们不抑制由气管分叉处机械刺激引起的咳嗽。在患有支气管炎的豚鼠中，色甘酸对由喉部刺激引起的咳嗽有镇咳作用，而可待因不抑制此类咳嗽。在暴露于二氧化硫的豚鼠中，色甘酸倾向于抑制由气管分叉处机械刺激引起的咳嗽。此外，色甘酸抑制了由血管紧张素转换酶抑制剂预处理增强的柠檬酸诱导的咳嗽，而可待因不抑制此类咳嗽。色甘酸还抑制缓激肽诱导的气道迷走传入神经放电，并显著抑制4-氨基吡啶诱导的气道迷走传入神经放电。这些发现表明，色甘酸的镇咳作用是由一种涉及外周神经系统的新机制介导的。
