人类疱疹病毒6型有哪些新进展？HHV-6感染的临床免疫病理学。

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

作者信息

Krueger G R, Sander C

机构信息

Institute of Pathology, University of Cologne, FRG.

出版信息

Pathol Res Pract. 1989 Dec;185(6):915-29. doi: 10.1016/s0344-0338(89)80299-7.

DOI:10.1016/s0344-0338(89)80299-7

PMID:2559396

Abstract

Human herpesvirus-6 (HHV-6), formerly known as human B-lymphotropic virus (HBLV), was first isolated in 1986 from patients with lymphoproliferative disorders and AIDS. Antibody prevalence against HHV-6 varies between about 60-80% indicating a widespread latent infection. Although HHV-6 infects in vivo primarily T-lymphocytes, it is associated with similar diseases as in infection with Epstein-Barr virus (EBV), a clearly B-lymphotropic virus. Reactivation of latent HHV-6 infection in patients with subnormal host defense may cause persistent active infection with so-called postinfectious chronic fatigue syndrome (PICFS) or may contribute to other pathologies such as immune deficiency itself, autoimmune disorders or progressive lymphoproliferation. Coinfection of CD4 cells by HHV-6 and human immunodeficiency virus (HIV 1) in AIDS patients can aggravate HIV-induced acquired immune deficiency. These characteristics of the only recently detected new virus justify further intense investigation.

摘要

人类疱疹病毒6型（HHV-6），以前称为人类B淋巴细胞嗜性病毒（HBLV），于1986年首次从患有淋巴增殖性疾病和艾滋病的患者中分离出来。针对HHV-6的抗体流行率在60%至80%之间变化，表明存在广泛的潜伏感染。尽管HHV-6在体内主要感染T淋巴细胞，但它与感染爱泼斯坦-巴尔病毒（EBV，一种明确的B淋巴细胞嗜性病毒）时出现的疾病相似。宿主防御功能低下的患者中潜伏的HHV-6感染重新激活可能导致所谓的感染后慢性疲劳综合征（PICFS）的持续活跃感染，或可能导致其他病理状况，如免疫缺陷本身、自身免疫性疾病或进行性淋巴增殖。艾滋病患者中HHV-6与人类免疫缺陷病毒（HIV 1）共同感染CD4细胞可加重HIV诱导的获得性免疫缺陷。这种最近才发现的新病毒的这些特征证明有必要进行进一步深入研究。