Grieco A, Caputo S, Silvestri E, Caradonna P, Bertoli A, Greco A V
Istituto di Clinica Medica Generale e Terapia Medica, Università Cattolica del Sacro Cuore, Rome, Italy.
Postgrad Med J. 1989 Dec;65(770):926-8. doi: 10.1136/pgmj.65.770.926.
Malignant fibrous histiocytoma of the bone is a very rare tumour mainly affecting long bones, and the most common presenting symptom is local pain. A case of malignant fibrous histiocytoma presenting with pyrexia of undetermined origin and arising in the sternum, a localization not previously described, is reported. The patient died with septic shock after multi-drug chemotherapy including high dose methotrexate treatment with citrovorum factor rescue.
骨恶性纤维组织细胞瘤是一种非常罕见的肿瘤，主要累及长骨，最常见的症状是局部疼痛。本文报告了一例发生于胸骨的骨恶性纤维组织细胞瘤，该病例以不明原因发热为表现，其发生部位此前未见报道。患者在接受包括大剂量甲氨蝶呤并亚叶酸钙解救的多药化疗后，死于感染性休克。
