Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; Centre for Nutrition Research, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Obesity (Silver Spring). 2015 Feb;23(2):313-21. doi: 10.1002/oby.20966. Epub 2014 Dec 31.
To evaluate the potential body weight-lowering effects of dietary supplementation with eicosapentaenoic acid (EPA) and α-lipoic acid separately or combined in healthy overweight/obese women following a hypocaloric diet.
This is a short-term double-blind placebo-controlled study with parallel design that lasted 10 weeks. Of the randomized participants, 97 women received the allocated treatment [Control, EPA (1.3 g/d), α-lipoic acid (0.3 g/d), and EPA+α-lipoic acid (1.3 g/d+0.3 g/d)], and 77 volunteers completed the study. All groups followed an energy-restricted diet of 30% less than total energy expenditure. Body weight, anthropometric measurements, body composition, resting energy expenditure, blood pressure, serum glucose, and insulin and lipid profile, as well as leptin and ghrelin levels, were assessed at baseline and after nutritional intervention.
Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. EPA supplementation significantly attenuated (P<0.001) the decrease in leptin levels that occurs during weight loss. Body weight loss improved lipid and glucose metabolism parameters but without significant differences between groups.
The intervention suggests that α-lipoic acid supplementation alone or in combination with EPA may help to promote body weight loss in healthy overweight/obese women following energy-restricted diets.
评估分别补充二十碳五烯酸（EPA）和α-硫辛酸，或联合补充这两种物质对遵循低热量饮食的超重/肥胖健康女性的潜在体重降低效果。
这是一项短期双盲安慰剂对照的平行设计研究，持续 10 周。在随机分组的参与者中，97 名女性接受了分配的治疗（对照组、EPA[1.3 g/d]、α-硫辛酸[0.3 g/d]和 EPA+α-硫辛酸[1.3 g/d+0.3 g/d]），77 名志愿者完成了研究。所有组都遵循能量摄入减少 30%的限制热量饮食，低于总能量消耗。在基线和营养干预后评估体重、人体测量学测量、身体成分、静息能量消耗、血压、血清葡萄糖和胰岛素及脂质谱以及瘦素和胃饥饿素水平。
补充α-硫辛酸的组体重减轻更明显（P<0.05）。EPA 补充显著减轻（P<0.001）了体重减轻期间瘦素水平的下降。体重减轻改善了脂质和葡萄糖代谢参数，但组间无显著差异。
干预表明，单独或联合补充α-硫辛酸和 EPA 可能有助于促进遵循低热量饮食的超重/肥胖健康女性减轻体重。
