Schultz Joachim E, Kanchan Kajal, Ziegler Miriam
Pharmazeutische Biochemie, Pharmazeutisches Institut, Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen H 4032, Hungary.
Int J Med Microbiol. 2015 Feb;305(2):243-51. doi: 10.1016/j.ijmm.2014.12.007. Epub 2014 Dec 23.
HAMP domains are small protein modules that predominantly operate as signal transducers in bacterial sensor proteins most of which are membrane delimited. The domain organization of such sensors has the HAMPs localized at the intersection between the membrane-anchored input sensor and the cytosolic output machinery. The data summarized here indicate that HAMP modules use a universal signaling language in balancing the communication between diverse membrane-bound input domains and cytosolic output domains that are completely foreign to each other.
HAMP结构域是小的蛋白质模块,主要作为细菌传感蛋白中的信号转导器发挥作用,其中大多数是膜界定的。这类传感器的结构域组织中,HAMP结构域位于膜锚定输入传感器和胞质输出机制的交叉点。此处总结的数据表明,HAMP模块使用一种通用的信号语言来平衡不同膜结合输入结构域和彼此完全不同的胞质输出结构域之间的通信。