囊性纤维化儿童和青少年的血清视黄醇水平与肺功能
Serum retinol levels and pulmonary function in children and adolescents with cystic fibrosis.
作者信息
Woestenenk J W, Broos N, Stellato R K, Arets H G M, van der Ent C K, Houwen R H J
机构信息
Internal Medicine and Dermatology, Dietetics, University Medical Centre Utrecht, KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands; Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Cystic Fibrosis Centre Utrecht, University Medical Centre Utrecht, KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands; Department of Paediatric Pulmonology, University Medical Centre Utrecht, KH.01.419.0, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
出版信息
J Cyst Fibros. 2015 May;14(3):392-7. doi: 10.1016/j.jcf.2014.11.007. Epub 2015 Jan 13.
BACKGROUND
It has been suggested that higher serum retinol levels could have protective effects on pulmonary function (PF) in patients with cystic fibrosis (CF). However, serum retinol levels will be transiently decreased during pulmonary exacerbation. Therefore, the extent of chronic pulmonary inflammation should be included when describing the association between PF and serum retinol. We assessed the longitudinal relation between serum retinol, immunoglobulin G (IgG) and PF in paediatric CF patients.
METHODS
We studied the serum retinol, IgG and forced expiratory volumes in one second (FEV(1)% pred.) of 228 CF patients during a seven-year follow up period. The cross-sectional and longitudinal relations between these variables were assessed.
RESULTS
Serum retinol, with medians levels between 1.2 and 1.4 μmol/l, were relatively stable, while median serum IgG gradually increased during the age years. The FEV(1)% pred. was longitudinally inversely associated with serum IgG and age, but not with serum retinol. Each g/l increase in serum IgG level was associated with an accelerated yearly decline in FEV(1)% pred. of 0.5% (95% CI -0.8 to -0.1, p=0.008), and each year increase in age was associated with a 1.7% (95% CI -2.1 to -1.3, p=0.000) decline in FEV(1)% pred. This effect was not observed with respect to serum retinol levels (95% CI -1.9 to 2.2, p=0.570).
CONCLUSIONS
In this large sample of children and adolescents with CF, we found no evidence that higher serum retinol levels had protective effects on PF.
背景
有人提出，较高的血清视黄醇水平可能对囊性纤维化（CF）患者的肺功能（PF）具有保护作用。然而，在肺部病情加重期间，血清视黄醇水平会暂时降低。因此，在描述PF与血清视黄醇之间的关联时，应纳入慢性肺部炎症的程度。我们评估了儿科CF患者血清视黄醇、免疫球蛋白G（IgG）与PF之间的纵向关系。
方法
我们研究了228例CF患者在七年随访期间的血清视黄醇、IgG和一秒用力呼气量（FEV(1)%预计值）。评估了这些变量之间的横断面和纵向关系。
结果
血清视黄醇水平中位数在1.2至1.4μmol/l之间，相对稳定，而血清IgG中位数在各年龄段逐渐升高。FEV(1)%预计值与血清IgG和年龄呈纵向负相关，但与血清视黄醇无关。血清IgG水平每升高1 g/l，FEV(1)%预计值每年加速下降0.5%（95%可信区间-0.8至-0.1，p = 0.008），年龄每增加一岁，FEV(1)%预计值下降1.7%（95%可信区间-2.1至-1.3，p = 0.000）。血清视黄醇水平未观察到这种效应（95%可信区间-1.9至2.2，p = 0.570）。
结论
在这个大量CF儿童和青少年样本中，我们没有发现证据表明较高的血清视黄醇水平对PF有保护作用。
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