Wang Jing, Li Xin, Zhang Da-Qi, Yang Chun-Sheng, Qi Yuan, Li Min-Shu, Shi Fu-Dong, Yang Li
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
J Neuroimmunol. 2015 Jan 15;278:26-9. doi: 10.1016/j.jneuroim.2014.12.006. Epub 2014 Dec 5.
Aquaporin-4 (AQP-4) antibody-positive longitudinally extensive transverse myelitis (LETM) is referred to as a neuromyelitis optica (NMO) spectrum disorder. We conducted an exploratory investigation of correlations between AQP-4 antibody serum levels, as determined by a fluorescent immunoprecipitation assay, and clinical characteristics in LETM. Expanded Disability Status Scores (EDSS) scores and number of segments of spinal cord involved were positively correlated to AQP-4 antibody levels. However, serum AQP-4 antibody levels were not correlated with the time to next attack or the conversion time of LETM to NMO, although seropositive LETM patients demonstrated a high conversion rate to NMO (78.1%).
水通道蛋白4（AQP - 4）抗体阳性的长节段横贯性脊髓炎（LETM）被称为视神经脊髓炎（NMO）谱系障碍。我们对通过荧光免疫沉淀法测定的AQP - 4抗体血清水平与LETM临床特征之间的相关性进行了探索性研究。扩展残疾状态评分（EDSS）得分和脊髓受累节段数与AQP - 4抗体水平呈正相关。然而，血清AQP - 4抗体水平与下次发作时间或LETM转化为NMO的时间无关，尽管血清阳性的LETM患者向NMO的转化率较高（78.1%）。
