Matsui H, Itano T, Etoh S, Tokuda M, Wang J H, Hatase O
Dept. of Physiology Kagawa Med. Sch., Japan.
Adv Exp Med Biol. 1989;255:369-75. doi: 10.1007/978-1-4684-5679-0_40.
Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
使用亚基特异性单克隆抗体，在大鼠脑中检测了钙调神经磷酸酶亚基A（60千道尔顿）和B（20千道尔顿）的免疫组织化学定位。亚基A的免疫反应性在海马体、纹状体和丘脑中丰富，但在新皮质中较弱。相反，亚基B的免疫反应性在皮质中更丰富，并且比亚基A更普遍存在。亚基A在大鼠脑中的分布与锌的分布非常吻合，锌是一种内在金属离子，也是钙调神经磷酸酶的有效抑制剂。
