Nishimura Yasumasa
Dept. of Radiation Oncology, Kinki University Faculty of Medicine.
Gan To Kagaku Ryoho. 2014 Dec;41(13):2539-42.
The development and successful clinical use of intensity modulated radiation therapy (IMRT) is a significant advance in radiation therapy. IMRT is particularly effective for cancers in complex anatomic regions such as the head and neck, and prostate, because the target volumes are contiguous to organs at risk. The success of IMRT strongly depends on the precise contouring of the target volumes and organs at risk. A significant benefit of IMRT with regard to xerostomia and quality of life has been reported for head and neck cancer. For prostate cancer, IMRT can deliver a high total dose of 76-80 Gy to the target volume without serious late toxicities.
调强放射治疗（IMRT）的发展及其在临床上的成功应用是放射治疗领域的一项重大进展。IMRT对于头颈部和前列腺等复杂解剖区域的癌症特别有效，因为靶区与危及器官相邻。IMRT的成功很大程度上取决于靶区和危及器官的精确轮廓勾画。对于头颈部癌，IMRT在口干症和生活质量方面具有显著益处。对于前列腺癌，IMRT可以向靶区给予76 - 80 Gy的高总剂量而不会产生严重的晚期毒性。
