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[三原发结肠癌伴腹膜播散的复发性异时性肝转移的全身化疗与手术——病例报告]

[Systemic chemotherapy and surgery for recurrent metachronous liver metastases with peritoneal dissemination from triple colon cancers-a case report].

作者信息

Kato Takaharu, Noda Hiroshi, Watanabe Fumiaki, Kakizawa Nao, Toyama Nobuyuki, Rikiyama Toshiki

机构信息

Dept. of Surgery, Saitama Medical Center, Jichi Medical University.

出版信息

Gan To Kagaku Ryoho. 2014 Dec;41(13):2615-7.

Abstract

Although the first-line treatment for liver metastases arising from colorectal cancer is surgery, it is unknown whether this treatment is equally effective for liver metastases with peritoneal dissemination. We report a case of long-term survival after oxaliplatin-based chemotherapy and surgery for metachronous liver metastases with peritoneal dissemination from triple colon cancer. A 76-year-old man with a history of stage III descending colon cancer developed recurrent localized peritoneal dissemination and multiple liver metastases 30 months after surgery. He underwent partial liver resection, partial peritoneal resection, and 8 courses of capecitabine plus oxalitlatin (XELOX). There has been no disease recurrence 75 months after the initial surgery. While though there is no consensus for treatment of liver metastasis with peritoneal dissemination, surgery combined with systemic chemotherapy may be beneficial.

摘要

尽管结直肠癌肝转移的一线治疗方法是手术,但对于伴有腹膜播散的肝转移,这种治疗是否同样有效尚不清楚。我们报告了一例经基于奥沙利铂的化疗及手术治疗后长期存活的病例,该患者为异时性三原发结肠癌伴腹膜播散的肝转移。一名有III期降结肠癌病史的76岁男性在手术后30个月出现复发性局限性腹膜播散和多发肝转移。他接受了部分肝切除术、部分腹膜切除术以及8个周期的卡培他滨加奥沙利铂(XELOX)治疗。初次手术后75个月未出现疾病复发。虽然对于伴有腹膜播散的肝转移的治疗尚无共识,但手术联合全身化疗可能有益。

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