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嵌合乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）亚病毒包膜颗粒在预先接种乙肝疫苗的动物中可诱导高效的抗丙肝病毒抗体产生。

Chimeric hepatitis B virus (HBV)/hepatitis C virus (HCV) subviral envelope particles induce efficient anti-HCV antibody production in animals pre-immunized with HBV vaccine.

作者信息

Beaumont Elodie, Roingeard Philippe

机构信息

INSERM U966, Université François Rabelais and CHRU de Tours, 10 bld Tonnelle, Tours, France.

INSERM U966, Université François Rabelais and CHRU de Tours, 10 bld Tonnelle, Tours, France.

出版信息

Vaccine. 2015 Feb 18;33(8):973-6. doi: 10.1016/j.vaccine.2015.01.007. Epub 2015 Jan 14.

DOI:10.1016/j.vaccine.2015.01.007
PMID:25596457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5666088/
Abstract

The development of an effective, affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. The recently described chimeric HBV-HCV subviral envelope particles could potentially be used for this purpose, as they could be produced by industrial procedures adapted from those established for the hepatitis B virus (HBV) vaccine. We show here, in an animal model, that pre-existing immunity acquired through HBV vaccination does not influence the immunogenicity of the HCV E2 protein presented by these chimeric particles. Thus, these chimeric HBV-HCV subviral envelope particles could potentially be used as a booster in individuals previously vaccinated against HBV, to induce protective immunity to HCV.

摘要

开发一种有效且价格合理的丙型肝炎病毒（HCV）预防性疫苗仍是医学上的一项优先任务。最近描述的嵌合型乙肝病毒-丙肝病毒亚病毒包膜颗粒有可能用于此目的，因为它们可以通过借鉴乙肝病毒（HBV）疫苗的现有工业生产流程来制备。我们在此动物模型中表明，通过接种乙肝疫苗获得的既往免疫力不会影响这些嵌合颗粒所呈现的丙肝病毒E2蛋白的免疫原性。因此，这些嵌合型乙肝病毒-丙肝病毒亚病毒包膜颗粒有可能用作曾接种过乙肝疫苗个体的加强针，以诱导对丙肝病毒的保护性免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3871/5666088/b7862b7b1292/halms1575077f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3871/5666088/b7862b7b1292/halms1575077f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3871/5666088/b7862b7b1292/halms1575077f1.jpg

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本文引用的文献

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将载脂蛋白 E 纳入 HBV-HCV 亚病毒包膜颗粒以改进肝炎疫苗策略。
Sci Rep. 2021 Nov 8;11(1):21856. doi: 10.1038/s41598-021-01428-7.
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To Include or Occlude: Rational Engineering of HCV Vaccines for Humoral Immunity.纳入或排除：HCV 疫苗体液免疫的理性工程。
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