Han Jay J, Kurillo Gregorij, Abresch Richard T, De Bie Evan, Nicorici Alina, Bajcsy Ruzena
Department of Physical Medicine and Rehabilitation, School of Medicine, University of California at Davis, 4860 Y Street, Suite 3850, Sacramento, California, 95817, USA.
Department of Electrical Engineering and Computer Science, College of Engineering, University of California at Berkeley, Berkeley, California, USA.
Muscle Nerve. 2015 Sep;52(3):344-55. doi: 10.1002/mus.24567. Epub 2015 Jun 3.
An innovative upper extremity 3-dimensional (3D) reachable workspace outcome measure acquired using the Kinect sensor is applied toward Duchenne/Becker muscular dystrophy (DMD/BMD). The validity, sensitivity, and clinical meaningfulness of this novel outcome measure are examined.
Upper extremity function assessment (Brooke scale and NeuroQOL questionnaire) and Kinect-based reachable workspace analyses were conducted in 43 individuals with dystrophinopathy (30 DMD and 13 BMD, aged 7-60 years) and 46 controls (aged 6-68 years).
The reachable workspace measure reliably captured a wide range of upper extremity impairments encountered in both pediatric and adult, as well as ambulatory and non-ambulatory individuals with dystrophinopathy. Reduced reachable workspaces were noted for the dystrophinopathy cohort compared with controls, and they correlated with Brooke grades. In addition, progressive reduction in reachable workspace correlated directly with worsening ability to perform activities of daily living, as self-reported on the NeuroQOL.
This study demonstrates the utility and potential of the novel sensor-acquired reachable workspace outcome measure in dystrophinopathy.
一种使用Kinect传感器获取的创新型上肢三维(3D)可达工作空间结果测量方法被应用于杜氏/贝克型肌营养不良症(DMD/BMD)。本研究对这一新型结果测量方法的有效性、敏感性和临床意义进行了检验。
对43例肌营养不良症患者(30例DMD和13例BMD,年龄7 - 60岁)和46例对照者(年龄6 - 68岁)进行了上肢功能评估(布鲁克量表和神经生活质量问卷)以及基于Kinect的可达工作空间分析。
可达工作空间测量方法能够可靠地捕捉到小儿和成人肌营养不良症患者以及能行走和不能行走患者所出现的广泛上肢损伤。与对照组相比,肌营养不良症队列的可达工作空间减小,且与布鲁克分级相关。此外,可达工作空间的逐渐减小与神经生活质量问卷中自我报告的日常生活活动能力恶化直接相关。
本研究证明了新型传感器获取的可达工作空间结果测量方法在肌营养不良症中的实用性和潜力。