酪氨酸酶模型系统中附加苯酚的单加氧作用：对酶促反应机制的影响
Monooxygenation of an appended phenol in a model system of tyrosinase: implications on the enzymatic reaction mechanism.
作者信息
Hamann Jessica Nadine, Rolff Malte, Tuczek Felix
机构信息
Christian-Albrechts-University Kiel, Max-Eyth-Straße 2, 24118 Kiel, Germany.
出版信息
Dalton Trans. 2015 Feb 21;44(7):3251-8. doi: 10.1039/c4dt03010a.
PMID:25597816
Abstract
A new tridentate N-donor ligand and its corresponding copper(i) complex have been synthesized to investigate the tyrosinase-like aromatic hydroxylation of an attached phenol. The results of the oxygenation reactions are compared to related systems having attached phenyl and catechol groups, respectively. The title complex is the first system mediating the monooxygenation of a phenol in the absence of an external base.
摘要
合成了一种新型三齿氮供体配体及其相应的铜（I）配合物，以研究连接的苯酚的酪氨酸酶样芳香族羟基化反应。将氧化反应的结果分别与连接有苯基和儿茶酚基团的相关体系进行比较。标题配合物是第一个在没有外部碱的情况下介导苯酚单加氧反应的体系。
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