N-乙酰基-7-、8-、9-脱氧-以及-4,7-二脱氧神经氨酸的侧链构象及其对CTP：N-酰基神经氨酸胞苷酰基转移酶激活的影响。
The side-chain conformations of N-acetyl-7-,8-,9-deoxy-, and -4,7-dideoxy-neuraminic acid and their effect on the activation of CTP:N-acylneuraminic acid cytidylyltransferase.
作者信息
Christian R, Schreiner E, Zbiral E, Schulz G
机构信息
Institut für Chemie der Universität für Bodenkultur Wien, Austria.
出版信息
Carbohydr Res. 1989 Dec 1;194:49-61. doi: 10.1016/0008-6215(89)85005-0.
PMID:2559792
Abstract
The conformations of the deoxy side-chain analogs of N-acetylneuraminic acid and of N-acetyl-4-deoxyneuraminic acid have been studied by n.m.r. spectroscopy, which allowed us to distinguish between local minima conformations suggested by hard-sphere calculations. The conformations were correlated with the activity with CTP: N-acetylneuraminic acid cytidylyltransferase (CMPsialate synthase; EC 2.7.7.43).
摘要
通过核磁共振光谱研究了N-乙酰神经氨酸和N-乙酰-4-脱氧神经氨酸的脱氧侧链类似物的构象，这使我们能够区分硬球计算所提出的局部最小构象。这些构象与CTP：N-乙酰神经氨酸胞苷酰基转移酶（CMP唾液酸合酶；EC 2.7.7.43）的活性相关。
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