Balijepalli Madhu Katyayani, Suppaiah Velan, Chin An-Me, Buru Ayuba Sunday, Sagineedu Sreenivasa Rao, Pichika Mallikarjuna Rao
Department of Pharmacology, Faculty of Medicine, MAHSA University, Jalan University Campus, JalanElmu, Off Jalan University, 59100, Kuala Lumpur, Malaysia.
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, JalanJalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
Pharmacognosy Res. 2015 Jan-Mar;7(1):38-44. doi: 10.4103/0974-8490.147197.
Swietenia macrophylla King. (Meliaceae) seeds (SMS); commonly known as sky fruit and locally known in Malaysia as Tunjuk Langit; have been used in traditional Malay medicine for the treatment of diabetes and hypertension. The people eat only a tiny amount of raw seed, weighing not more than 5 mg.
To evaluate the safety of Swietenia macrophylla seeds (SMS) at a single-dose oral administration of 2 g/kg body weight (bw) in sprague dawley (SD) rats.
Eight-week old male and female SD rats were administered a single-oral dose of 2g/kg bw. The rats' general behavior, and toxic signs were observed throughout the 14-day study period. The food and water intake by rats and their body weight were monitored during the study period. At the end of the study period, the relative weights of the organs (lung, liver, spleen, heart, kidney, testis, stomach); the hematological and biochemical parameters were measured; the architecture and histology of the organs (liver, kidney and lungs) were observed.
Oral administration of SMS to rats did not affect, either food or water intake; relative organ weight of vital organs; the hematological and biochemical parameters; did not show significant changes in the architecture and histology of vital organs. Overall, there were neither signs of toxicity nor deaths recorded during the study period.
The rat dose of 2 g/kg bw is equivalent to the human dose of 325 mg/kg bw, which is well below the usual amount consumed by people, did not show any signs of toxicity in rats.
大叶桃花心木（楝科）种子（SMS）；俗称望天果，在马来西亚当地被称为Tunjuk Langit；已被用于传统马来医学中治疗糖尿病和高血压。人们仅食用极少量的生种子，重量不超过5毫克。
评估在斯普拉格-道利（SD）大鼠中口服单剂量2克/千克体重（bw）的大叶桃花心木种子（SMS）的安全性。
对8周龄的雄性和雌性SD大鼠口服单剂量2克/千克bw。在整个14天的研究期间观察大鼠的一般行为和毒性体征。在研究期间监测大鼠的食物和水摄入量以及体重。在研究期结束时，测量各器官（肺、肝、脾、心、肾、睾丸、胃）的相对重量；检测血液学和生化参数；观察各器官（肝、肾和肺）的结构和组织学。
给大鼠口服SMS对食物或水摄入量、重要器官的相对器官重量、血液学和生化参数均无影响；重要器官的结构和组织学未显示出显著变化。总体而言，在研究期间既没有毒性迹象也没有死亡记录。
大鼠剂量2克/千克bw相当于人类剂量325毫克/千克bw，远低于人们通常食用的量，在大鼠中未显示出任何毒性迹象。
