Bhattacharya M K, Kanungo S, Ramamurthy T, Rajendran K, Sinha A, Bhattacharya A, Sarkar B Sharma
National Institute of Cholera & Enteric Disease, Kolkata, India;
ID & BG Hospital, Kolkata, India;
Int J Biomed Sci. 2014 Dec;10(4):248-51.
To evaluate the efficacy of single dose Azithromycin (1 gram) in treatment of cholera in adults. A randomized, controlled clinical trial on 120 adults with acute watery diarrhoea and moderate to severe dehydration compared the efficacy of azithromycin (1 gram) single dose and Norfloxacin (400 mg) twice daily for three days in treating cholera. Data were analysed for 64 patients who were stool culture positive for Vibrio cholerae. In conjunction with rehydration therapy, 32 patients received Azithromycin and 32 patients received Norfloxacin. Patients in the two treatment groups had comparable clinical characteristics on admission.
Result shows Azithromycin and Norfloxacin has got almost similar efficacy in reducing stool output, duration of diarrhoea and fluid requirement in cholera positive cases.
评估单剂量阿奇霉素(1克)治疗成人霍乱的疗效。一项针对120名患有急性水样腹泻且伴有中度至重度脱水的成年人的随机对照临床试验,比较了单剂量阿奇霉素(1克)和诺氟沙星(400毫克)每日两次、连用三天治疗霍乱的疗效。对64例霍乱弧菌粪便培养呈阳性的患者的数据进行了分析。在补液治疗的同时,32例患者接受阿奇霉素治疗,32例患者接受诺氟沙星治疗。两个治疗组的患者入院时临床特征具有可比性。
结果显示,在减少霍乱阳性病例的粪便排出量、腹泻持续时间和液体需求量方面,阿奇霉素和诺氟沙星的疗效几乎相似。