Tranquilli A L, Rabini R A, Cugini A M, Cester N, Valensise H, Romanini C, Bertoli E, Mazzanti L
Department of Obstetrics and Gynecology, University of Ancona, Italy.
Int J Cardiol. 1989;25 Suppl 1:S53-5. doi: 10.1016/0167-5273(89)90093-4.
The enzymatic activities of Na+/K+ ATPase and Ca2+ ATPase were determined on erythrocyte membranes from 9 normotensive and 9 gestational hypertensive pregnant women near term. A reduction in the activity of the Na+/K+ ATPase and a relative increase in the activity of the Ca2+ ATPase were found in the hypertensive patients, possibly due to a conformational alteration of erythrocyte membranes. This observation supports the possible role of the transmembrane cation transport in the pathogenesis of gestational hypertension.
对9名血压正常的足月孕妇和9名妊娠高血压孕妇的红细胞膜进行了钠钾ATP酶和钙ATP酶的酶活性测定。发现高血压患者的钠钾ATP酶活性降低，钙ATP酶活性相对增加，这可能是由于红细胞膜的构象改变所致。这一观察结果支持了跨膜阳离子转运在妊娠高血压发病机制中可能发挥的作用。
