Phillips D I, Osmond C
Department of Medicine, University of Wales College of Medicine, Health Park, Cardiff, UK.
Int J Epidemiol. 1989 Dec;18(4):907-10. doi: 10.1093/ije/18.4.907.
A controlled trial of iodine supplementation comparing oral with intramuscular iodized oil has been carried out in an iodine deficient area of Zaire. Two years after the administration of 2 ml of oral iodized oil to the population of four villages the overall goitre prevalence had fallen from 64 to 54%. In a further two villages given 2 ml of intramuscular oil the prevalence fell from 65 to 50%. The effectiveness of supplementation was also assessed by measuring changes in thyroid function in women of reproductive age. Among women in the villages given oral iodized oil, the geometric mean thyroxine concentration, measured in dried bloodspots, rose from 27.2 to 52.6 nmol/L at the two-year follow-up. This was similar to the response of the intramuscularly treated villages in which thyroxine levels rose from 32.1 to 65.4 nmol/L. There was no change in goitre prevalence or thyroid function in two control villages. Oral iodized oil is a cheaper and simpler alternative to the injected form providing effective iodine prophylaxis for up to two years after a single dose.
在扎伊尔一个碘缺乏地区进行了一项比较口服与肌内注射碘化油补充碘的对照试验。在给四个村庄的人群口服2毫升碘化油两年后，总体甲状腺肿患病率从64%降至54%。在另外两个接受2毫升肌内注射油的村庄，患病率从65%降至50%。还通过测量育龄妇女甲状腺功能的变化来评估补充碘的效果。在口服碘化油的村庄的妇女中，在两年随访时，干血斑中测得的甲状腺素几何平均浓度从27.2纳摩尔/升升至52.6纳摩尔/升。这与肌内注射治疗的村庄的反应相似，在这些村庄中甲状腺素水平从32.1纳摩尔/升升至65.4纳摩尔/升。两个对照村庄的甲状腺肿患病率和甲状腺功能没有变化。口服碘化油是注射形式的一种更便宜、更简单的替代方法，单次给药后可提供长达两年的有效碘预防。
