Phillips D I, Lusty T D, Osmond C, Church D
MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.
Int J Epidemiol. 1988 Mar;17(1):142-7. doi: 10.1093/ije/17.1.142.
A community-based controlled trial of iodine supplementation comparing oral or intramuscular iodized oil with oral potassium iodide has been carried out in 23 severely iodine-deficient villages in Eastern Zaire. The overall goitre prevalence in the population (n = 5999) was 61% and mean urinary iodine excretion in sample of 57 women 10.9 (SD 6.8) micrograms/g creatinine. All adults in three groups of four villages were given single doses of potassium iodide of 0.5 g, 1.0 g, and 2.0 g respectively. A fourth group was given oral iodized oil (2 ml) and a fifth placebo-treated. A further three villages were given intramuscular iodized oil (2 ml). The effectiveness of supplementation was assessed by measurements of bloodspot thyroxine (T4) concentration in women of reproductive age in the villages. The effects of iodide were small and inconsistent. Eight months after supplementation with oral iodized oil the distribution of T4 concentrations was similar to that seen with intramuscular oil. We conclude that oral iodized oil is an effective alternative to injected oil and would be feasible for iodine supplementation in remote areas with untrained people.
在扎伊尔东部23个严重缺碘村庄开展了一项基于社区的对照试验，比较口服或肌内注射碘化油与口服碘化钾补充碘的效果。研究人群（n = 5999）的总体甲状腺肿患病率为61%，57名女性样本的尿碘排泄均值为10.9（标准差6.8）微克/克肌酐。在四组四个村庄中的所有成年人分别给予0.5克、1.0克和2.0克单剂量的碘化钾。第四组给予口服碘化油（2毫升），第五组给予安慰剂治疗。另外三个村庄给予肌内注射碘化油（2毫升）。通过测量这些村庄育龄妇女血斑甲状腺素（T4）浓度来评估补充碘的效果。碘化物的效果较小且不一致。口服碘化油补充八个月后，T4浓度分布与肌内注射油相似。我们得出结论，口服碘化油是注射用油的有效替代方法，对于在有未受过培训人员的偏远地区补充碘是可行的。
