通过单光子发射计算机断层扫描（SPECT）对人脑中的苯二氮䓬受体进行成像。

Imaging benzodiazepine receptors in the human brain by single photon emission computed tomography (SPECT).

作者信息

Höll K, Deisenhammer E, Dauth J, Carmann H, Schubiger P A

机构信息

Department of Neuronuclear Medicine and Neurophysiology, Wagner-Jauregg Hospital, Linz, Switzerland.

出版信息

Int J Rad Appl Instrum B. 1989;16(8):759-63. doi: 10.1016/0883-2897(89)90158-x.

DOI:10.1016/0883-2897(89)90158-x

PMID:2559905

Abstract

Recently, [123I]Ro16-0154 has been introduced as a potential benzodiazepine (BZD) receptor imaging tracer for SPECT. We investigated the biodistribution of [123I]Ro16-0154 in humans and compared it with the animal data. There was a rapid and high 123I-uptake in the brain comparable to rCBF. In the following images, however, regionally different changes were observed, resulting in a subsequent intracerebral retention parallel to the known distribution of BZD receptors. The results suggest that [123I]Ro16-0154 is of potential clinical use as a BZD receptor imaging agent.

摘要

最近，[123I]Ro16 - 0154已被引入作为一种潜在的用于单光子发射计算机断层扫描（SPECT）的苯二氮䓬（BZD）受体显像剂。我们研究了[123I]Ro16 - 0154在人体中的生物分布，并将其与动物数据进行了比较。大脑中存在与局部脑血流量（rCBF）相当的快速且高度的123I摄取。然而，在随后的图像中，观察到了区域差异变化，导致随后脑内滞留情况与已知的BZD受体分布平行。结果表明，[123I]Ro16 - 0154作为一种BZD受体显像剂具有潜在的临床应用价值。