Lee Zhenghong, Luo Guangbin
Professor of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Associate professor of Genetics, Case Western Reserve University, Cleveland, OH, USA.
J Fasting Health. 2014 Spring;2(2):62-64.
Positron emission tomography (PET) imaging using 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) has proven valuable in the diagnosis, staging and restaging for many cancers. However, its application for liver cancer has remained limited owing in part to the relatively high background uptake of the tracer in the liver plus the significant variability of the tumor specific uptake in liver cancer among patients. Thus, for primarily liver cancer, in particular, hepatocellular carcinoma (HCC), radio-tracers with better tumor-enhancing uptake/retention are still sought in order to harness the great power of PET imaging. Here, we reviewed some recent investigations with lipid-based small molecule PET radio-tracers with relevance to fasting, and discuss their potential in the diagnosis and staging of HCCs.
使用2-脱氧-2-[F-18]氟-D-葡萄糖（FDG）的正电子发射断层扫描（PET）成像已被证明在许多癌症的诊断、分期和再分期中具有重要价值。然而，其在肝癌中的应用仍然有限，部分原因是示踪剂在肝脏中的背景摄取相对较高，以及肝癌患者中肿瘤特异性摄取的显著变异性。因此，特别是对于原发性肝癌，尤其是肝细胞癌（HCC），仍在寻找具有更好肿瘤增强摄取/滞留的放射性示踪剂，以充分发挥PET成像的强大功能。在此，我们回顾了一些近期关于与禁食相关的基于脂质的小分子PET放射性示踪剂的研究，并讨论了它们在HCC诊断和分期中的潜力。
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