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创伤后应激障碍与抑郁症：心力衰竭患者疾病负担的潜在途径。

Posttraumatic stress and depression: potential pathways to disease burden among heart failure patients.

作者信息

Taylor-Clift April, Hobfoll Stevan E, Gerhart James I, Richardson DeJuran, Calvin James E, Powell Lynda H

机构信息

a Behavioral Sciences Department , Rush University Medical Center , 1645 West Jackson Boulevard, Suite 400, Chicago , IL 60612 , USA.

b Lake Forest College , Young Hall 125, 555 Sheridan Road, Lake Forest , IL 60045 , USA.

出版信息

Anxiety Stress Coping. 2016;29(2):139-52. doi: 10.1080/10615806.2015.1006206. Epub 2015 Feb 26.

DOI:10.1080/10615806.2015.1006206
PMID:25599115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4550578/
Abstract

BACKGROUND AND OBJECTIVES

Posttraumatic stress disorder (PTSD) and Major Depressive Disorder (MDD) are associated with high disease burden. Pathways by which PTSD and MDD contribute to disease burden are not understood.

DESIGN

Path analysis was used to examine pathways between PTSD symptoms, MDD symptoms, and disease burden among 251 low-income heart failure patients.

METHODS

In Model 1, we explored the independent relationship between PTSD and MDD symptoms on disease burden. In Model 2, we examined the association of PTSD symptoms and disease burden on MDD symptoms. We also examined indirect associations of PTSD symptoms on MDD symptoms, mediated by disease burden, and of PTSD symptoms on disease burden mediated by MDD symptoms.

RESULTS

Disease burden correlated with PTSD symptoms (r = .41; p < .001) and MDD symptoms (r = .43; p < .001) symptoms. Both models fit the data well and displayed comparable fit. MDD symptoms did not mediate the association of PTSD symptoms with disease burden. Disease burden did mediate the relationship between PTSD symptoms and MDD symptoms.

CONCLUSIONS

Results support the importance of detection of PTSD in individuals with disease. Results also provide preliminary models for testing longitudinal data in future studies.

摘要

背景与目的

创伤后应激障碍（PTSD）和重度抑郁症（MDD）与高疾病负担相关。PTSD和MDD导致疾病负担的途径尚不清楚。

设计

采用路径分析来研究251名低收入心力衰竭患者中PTSD症状、MDD症状和疾病负担之间的途径。

方法

在模型1中，我们探讨了PTSD和MDD症状与疾病负担之间的独立关系。在模型2中，我们研究了PTSD症状和疾病负担与MDD症状之间的关联。我们还研究了由疾病负担介导的PTSD症状与MDD症状之间的间接关联，以及由MDD症状介导的PTSD症状与疾病负担之间的间接关联。

结果

疾病负担与PTSD症状（r = 0.41；p < 0.001）和MDD症状（r = 0.43；p < 0.001）相关。两个模型都很好地拟合了数据，并显示出可比的拟合度。MDD症状并未介导PTSD症状与疾病负担之间的关联。疾病负担确实介导了PTSD症状与MDD症状之间的关系。

结论

结果支持在患有疾病的个体中检测PTSD的重要性。结果还为未来研究中测试纵向数据提供了初步模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/b819db77acab/nihms-658206-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/bcc37947681b/nihms-658206-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/1fc3a36db6fb/nihms-658206-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/b819db77acab/nihms-658206-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/bcc37947681b/nihms-658206-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/1fc3a36db6fb/nihms-658206-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/4550578/b819db77acab/nihms-658206-f0004.jpg

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