Department of Electrical and Computer Engineering and Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore 117576.
Lab Chip. 2015 Mar 21;15(6):1445-50. doi: 10.1039/c4lc01451k.
We developed a novel gradient generator to achieve long range and linear chemical gradients with a dynamic control function. The length of the gradient can be on the centimetre scale. The gradient profile can be tuned by changing the flow rates. The device can work in both high flow rate regimes with large shear stress and low flow rate regimes with minimum shear stress. The drug screening function was demonstrated by the viability test of PC-9 cancer cells.
我们开发了一种新型的梯度发生器，实现了具有动态控制功能的长程线性化学梯度。梯度的长度可以达到厘米级。通过改变流速可以调整梯度轮廓。该设备可以在高流速大剪切应力和低流速最小剪切应力的两种状态下工作。通过对 PC-9 癌细胞的生存能力测试，验证了该设备的药物筛选功能。
